By F. Sherwood. Taylor
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Roberts,M. , Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans, Nat. Med. 9 (6), 729–735, 2003. 54. , and Xiao, W, Generation and characterization of chimeric recombinant AAV vectors, Mol Ther. 7 (3), 419–425, 2003. 55. , Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts, Nature 424 (6944), 99–103, 2003. 56. , Targeting adenovirus, Gene Ther. 7 (2), 110–114, 2000. 57. Beutler, B.
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However, there are certain drawbacks that come with that improved targeting and delivery. Surface components used by viral particles for selective tissue and cellular targeting make them more easily recognized by the immune system. In response, viruses have acquired additional characteristics that allow them to evade the immune system or to manipulate it to their own benefit. In doing so, these viruses have become so aggressive that they usurp or modify the normal function of the host cell to the extent that their infections result in some associated pathological condition.