Advances in Calcium Phosphate Biomaterials by Besim Ben-Nissan

By Besim Ben-Nissan

Advances in Calcium Phosphate Biomaterials offers a entire, state of the art evaluation of the most recent advances in constructing calcium phosphate biomaterials and their functions in drugs. It covers the basic buildings, synthesis tools, characterization equipment, and the actual and chemical homes of calcium phosphate biomaterials, in addition to the synthesis and houses of calcium phosphate-based biomaterials in regenerative medication and their medical functions. The publication brings jointly those new techniques, mechanisms and strategies in contributions by means of either younger and “veteran” lecturers, clinicians, and researchers to ahead the data and services on calcium phosphate and similar fabrics. for this reason, the publication not just covers the basics but in addition open new avenues for assembly destiny demanding situations in study and scientific applications.

Besim Ben-Nissan is a Professor of Chemistry and Forensic technology on the collage of expertise, Sydney, Australia

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5 Synthetic Apatites as Bone-Substitute Materials The first successful use of a calcium phosphate reagent in bone repair was reported by Albee in 1920 [62], followed more than 50 years later by the first clinical study by Nery et al. ” X-ray diffraction analysis of Nery’s material years later revealed that the “TCP” consisted of a mixture of HAp and “-TCP with a “-TCP/HAp ratio of 20/80 [20] and was thus renamed “BCP” [64]. Similarity in composition of the synthetic apatite to biologic apatite was the rationale for the development of calcium-phosphate-based biomaterials for bone repair, substitution, and augmentation and as scaffolds for bone and tooth regeneration.

Bioactivity is defined as the property of the material to develop a direct, adherent, and strong bonding and interface with the bone tissue [84, 85]. Bioactivity is demonstrated in vitro and in vivo by the ability of the material to form carbonate apatite on the surface from the simulated body fluid in vitro [56] or biologic fluid in vivo in osseous or non-osseous sites [65, 66, 86, 87]. Osteoconductivity is the property of the material that allows attachment, proliferation, migration, and phenotypic expression of bone cells leading to the formation of new bone in direct opposition to the biomaterial [84].

LeGeros RZ, Tung MS (1983) Chemical stability of carbonate and fluoride containing apatites. Caries Res 17:419–429 32. LeGeros RZ, LeGeros JP, Trautz OR, Klein E (1971) Conversion of monetite, CaHPO4 , to carbonate apatite: effect on crystallinity. Adv X-ray Appl 14:57–66 33. Margolis HC, Moreno EC (1985) Kinetic and thermodynamic aspects of enamel demineralization. Caries Res 19:22–35 34. LeGeros RZ (1982) Chemical and crystallographic events in caries. J Dent Res 69:567–574 35. Driessens FCM (1982) In moral aspects of dentistry.

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