Animal Models in Toxicology by Shayne C. Gad

By Shayne C. Gad

Although i've got but to learn the publication in its entirety, i've got skimmed via numerous chapters & i locate that a lot of the ideas seem to be written in redundancy. probably i've got excessive expectancies, yet maybe options which are played within the comparable demeanour among species can be consolidated and referenced. the knowledge for genuine toxicology within the a variety of species is especially precious.

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1982). Biotransformation of drugs and other xenobiotics during postnatal development. Pharmacol. Ther. 16, 377–429. , and Nebert, D. (1978). Correlation of type I, type II, and reverse type I, difference spectra with absolute changes in spin state of hepatic microsomal cytochrome P-450 iron from five mammalian species J. Biol. Chem. 253, 1048–1058. , and Way, E. ). (1972). Fundamentals of drug metabolism and drug disposition. Baltimore: Williams & Wilkins. , and Migdalof, B. H. (1983). Induction of hepatic drug-metabolizing enzymes in rats, dogs, and monkeys after repeated administration of an anti-inflammatory hexahydroindazole.

The genetic groundwork was laid for most of the strains of inbred mice currently in use by researchers such as William E. Castle, Clarence C. Little, and Leonell C. Strong during the period of about 1900 to 1930 (Morse 1981). Although highly inbred strains have proven invaluable in fields such as genetics and histocompatibility research, a school of thought developed that random bred or specifically outbred strains might more closely represent man in many areas of medical research. A random breeding program attempts to achieve a level of genetic variability similar to the initial (noninbred) population, and in so doing, preserve the “hybrid vigor” associated with heterozygosity.

J. Bridges and L. Chasseaud, 11–33. London: Taylor & Francis. , and Bend, J. (1977). Glutathione S-transferases. In Biological reactive intermediates: Formation, toxicity and inactivation, eds. D. Jallow, J. Kocsis, R. Snyder, and H. Vanio, 207–236. New York: Plenum. , and Hammons, G. (1987). The role of cytochrome P-450 in the metabolism of chemical carcinogens. In Mammalian cytochrome P450, Vol. 1, ed. F. Guengerich, 1–54. Boca Raton, FL: CRC Press. Kato, R. (1979). Characteristics and differences in the hepatic mixed function oxidases of different species Pharmacol.

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