Anticancer Drug Toxicity: Prevention, Management, and by Hans-Peter Lipp

By Hans-Peter Lipp

Containing the newest findings at the toxicity of a variety of chemotherapeutic brokers, this up to the moment reference bargains professional analyses at the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity ·explores healing drug tracking (TDM) as a style of maximizing the efficacy, and minimizing the risks, of chemotherapy ·presents an enormous quantity of scientific pharmacokinetic facts on cytostatic medicines ·offers a complete category of toxicity styles linked to using cytotoxic medications ·analyzes the pharmacokinetics of alkylating brokers, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and different cytotoxic brokers ·highlights the pharmacogenetics of 6-mercaptopurine and its medical value ·explicates toxicity on the subject of the lungs, kidneys, center, and gonads ·examines issues as a result of asparaginase arrangements ·reviews forms of secondary malignancy corresponding to leukemias, ovarian melanoma, testicular melanoma, breast melanoma, secondary sturdy neoplasias, and Hodgkin's affliction ·clarifies the knowledge of toxicity as a vital point in supportive administration of melanoma treatment ·and extra! An vastly sensible consultant for daily medical perform, in addition to a resource of notion for additional examine within the box, Anticancer Drug Toxicity is a useful reference for medical and scientific oncologists; medical institution, business, and medical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and scientific tuition scholars in those disciplines.

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Atropine effects on delayed discrimination performance of rats, Pharmacol. Biochem. , 32, 971–975, 1989. 103. , Cholinergic effects on fear conditioning II: nicotinic and muscarinic modulations of atropine-induced disruption of the degraded contingency effect, Psychopharmacology, 5, 5, 2005. 104. , Post-trial injection of atropine into the caudate nucleus interferes with longterm but not with short-term retention of passive avoidance, Behav. , 42, 81–84, 1984. 105. , Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats, J.

99, 979–1005, 1985. 100. G. , Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spatial memory task, Neurobiol. Aging, 14, 487–497, 1993. 101. , The effects of novel, selective 5-hydroxytryptamine (5-HT)4 receptor ligands in rat spatial navigation, Neuropharmacology, 36, 689–696, 1997. 102. , Atropine effects on delayed discrimination performance of rats, Pharmacol. Biochem. , 32, 971–975, 1989. 103. , Cholinergic effects on fear conditioning II: nicotinic and muscarinic modulations of atropine-induced disruption of the degraded contingency effect, Psychopharmacology, 5, 5, 2005.

Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats, J. , 16, 313–319, 2002. fm Page 21 Tuesday, May 30, 2006 12:28 PM 3 Nicotinic Receptor Antagonists in Rats Cindy S. Roegge and Edward D. 32 INTRODUCTION Nicotinic acetylcholine-receptor systems are critical neural components of cognitive functions. Nicotine and nicotinic agonists have been shown to improve cognition in rats in numerous studies [13–15, 27, 31, 59]. Similarly, nicotinic-receptor antagonists — the subject of this chapter — can cause cognitive impairments in rats.

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